ASUPAN VITAMIN D YANG KURANG BERISIKO MENINGKATKAN FREKUENSI KEJADIAN ALERGI SECARA UMUM PADA PEREMPUAN DEWASA DI KOTA BOGOR
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Abstract
Vitamin D deficiency is not only caused by disease, but also by insufficient intake. Insufficient vitamin D levels are associated with an increased incidence of allergies. This study aimed to determine the relationship between the source of vitamin D intake and the frequency of allergies in adult women in Bogor City. This research used a cross-sectional design involving 395 women aged 19-49 years and domiciled in Bogor City from August-November 2023. The sampling technique used was purposive sampling based on inclusion criteria. Data collection was carried out by filling out a questionnaire. Bivariate data were analyzed using chi-square. The results of the study show that consumption of vitamin D has a significant effect on the incidence of allergies, where people who consume vitamin D are less at risk of developing allergies (allergic and not allergic) (0.021) and is supported by the statement that the frequency of administration of vitamin D apparently influences the risk of not experiencing allergies ( 0.033). The results showed that intake of other sources of vitamin D: fish (p=0.359), cod liver oil supplements (p=0.106), milk enriched with vitamin D (p=0.844), dairy products enriched with vitamin D (p=0.503) , is not significantly related to the frequency of allergic events. The conclusion is regular consumption of vitamin D supplements can help reduce the frequency of allergies. Further research on the effects of immunomodulation and allergy prevention with experimental approaches is needed. Future research suggestions should investigate the optimal dose of vitamin D supplements for allergy prevention.
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References
R. Hidayat, S. Setiati, and P. Soewondo, “The association between vitamin D deficiency and type 2 diabetes mellitus in elderly patients.,” Acta Med. Indones., vol. 42, no. 3, 2010.
G. Bivona, L. Agnello, and M. Ciaccio, “The immunological implication of the new Vitamin D metabolism,” Central European Journal of Immunology, vol. 43, no. 3. pp. 331–334, 2018. doi: 10.5114/ceji.2018.80053.
J. R. Goldsmith, “Vitamin d as an immunomodulator: Risks with deficiencies and benefits of supplementation,” Healthcare (Switzerland), vol. 3, no. 2. MDPI, pp. 219–232, Jun. 2015. doi: 10.3390/healthcare3020219.
J. Khare, B. Reddy, S. Nalla, P. Srivastava, J. Wadhwa, and P. Deb, “Vitamin D deficiency and its association with thyroid peroxidase antibodies positive hypothyroidism - Experience in a tertiary center in South India,” Med. J. Dr. D.Y. Patil Univ., vol. 10, no. 4, pp. 355–358, 2017, doi: 10.4103/MJDRDYPU.MJDRDYPU_252_16.
Z. J. Morse and M. S. Horwitz, “Innate viral receptor signaling determines type 1 diabetes onset,” Frontiers in Endocrinology, vol. 8, no. SEP. pp. 1–10, 2017. doi: 10.3389/fendo.2017.00249.
I. Papaioannou, G. Pantazidou, Z. Kokkalis, N. Georgopoulos, and E. Jelastopulu, “Vitamin D Deficiency in Elderly With Diabetes Mellitus Type 2: A Review,” Cureus, 2021, doi: 10.7759/cureus.12506.
M. G. Fawwaz, P. Dokter, and F. Kedokteran, “Peranan Vitamin D Pada Pasien Covid-19,” J. Holist. Tradit. Med., vol. 6, no. 02, 2021.
A. S. Türkmen and I. Kalkan, “Vitamin D Deficiency in Children: Health Consequences and Prevention,” in Food Quality: Balancing Health and Disease: Volume 13, 2018. doi: 10.1016/B978-0-12-811442-1.00015-8.
P. Singh, M. Kumar, and S. Al Khodor, “Vitamin D deficiency in the Gulf Cooperation Council: Exploring the triad of genetic predisposition, the gut microbiome and the immune system,” Frontiers in Immunology, vol. 10, no. MAY. 2019. doi: 10.3389/fimmu.2019.01042.
F. F. Yani, “Peran Vitamin D pada Penyakit Respiratori Anak,” J. Kesehat. Andalas, vol. 8, no. 1, 2019, doi: 10.25077/jka.v8i1.986.
G. S. Octavius, V. A. Daleni, G. Angeline, and C. Virliani, “A systematic review and meta-analysis of prevalence of vitamin D deficiency among Indonesian pregnant women: a public health emergency,” AJOG Glob. Reports, vol. 3, no. 2, p. 100189, 2023, doi: 10.1016/j.xagr.2023.100189.
M. Hoxha, M. Zoto, L. Deda, and G. Vyshka, “Vitamin D and Its Role as a Protective Factor in Allergy.,” Int. Sch. Res. Not., vol. 2014, p. 951946, 2014, doi: 10.1155/2014/951946.
K. Rak and M. Bronkowska, “Immunomodulatory effect of Vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus-A narrative review,” Molecules, vol. 24, no. 1. 2019. doi: 10.3390/molecules24010053.
B. Yosephin, A. Khomsan, D. Briawan, and R. Rimbawan, “Vitamin D plus calcium supplementation increased serum 25(OH)D on reproductive age women workers,” Asian Pacific J. Trop. Dis., vol. 5, no. 11, pp. 877–880, Nov. 2015, doi: 10.1016/S2222-1808(15)60948-3.
L. O’Mahony, M. Stepien, M. J. Gibney, A. P. Nugent, and L. Brennan, “The potential role of vitamin D enhanced foods in improving vitamin D status,” Nutrients, vol. 3, no. 12, pp. 1023–1041, 2011, doi: 10.3390/nu3121023.
O. Aksonova, D. Torianyk, D. Slivar, and S. Gubsky, “Evaluation of the Intake of Vitamin D in Daily Food Rations by Students,” 2022. doi: 10.3390/iecn2022-12392.
G. Gafvelin, “Vitamin D and allergies,” J. Serbian Chem. Soc., vol. 78, no. 3, pp. 353–363, 2013, doi: 10.2298/JSC121022003G.
G. Murdaca, A. Allegra, A. Tonacci, C. Musolino, L. Ricciardi, and S. Gangemi, “Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases,” Biomedicines, vol. 10, no. 8, 2022, doi: 10.3390/biomedicines10081877.
A. Giannetti, L. Bernardini, J. Cangemi, M. Gallucci, R. Masetti, and G. Ricci, “Role of Vitamin D in Prevention of Food Allergy in Infants,” Frontiers in Pediatrics, vol. 8. 2020. doi: 10.3389/fped.2020.00447.
C. Benetti, P. Comberiati, C. Capristo, A. Boner, and D. Peroni, “Therapeutic Effects of Vitamin D in Asthma and Allergy,” Mini-Reviews Med. Chem., vol. 15, no. 11, 2015, doi: 10.2174/1389557515666150519110640.
J. Lemeshow, S. and David, Besar Sampel dalam Penelitian Kesehatan (terjemahan). Yogyakarta: Gadjah Mada University Press, 1997.
H. Mirzakhani, A. Al-Garawi, S. T. Weiss, and A. A. Litonjua, “Vitamin D and the development of allergic disease: How important is it?,” Clinical and Experimental Allergy, vol. 45, no. 1. 2015. doi: 10.1111/cea.12430.
K. Hufnagl and E. Jensen-Jarolim, “Vitamin A and D in allergy: From experimental animal models and cellular studies to human disease,” Allergo J. Int., vol. 27, no. 3, pp. 72–78, 2018, doi: 10.1007/s40629-018-0054-2.
P. Tuchinda, K. Kulthanan, L. Chularojanamontri, S. Arunkajohnsak, and S. Sriussadaporn, “Relationship between vitamin D and chronic spontaneous urticaria: A systematic review,” Clinical and Translational Allergy, vol. 8, no. 1. 2018. doi: 10.1186/s13601-018-0234-7.
S. Kılıç, F. Sılan, M. M. Hız, S. Işik, Z. Ögretmen, and Özdemir, “Vitamin D receptor gene BSMI, FOKI, APAI, and TAQI polymorphisms and the risk of atopic dermatitis,” J. Investig. Allergol. Clin. Immunol., vol. 26, no. 2, 2016, doi: 10.18176/jiaci.0020.
K. J. G. Schulkes et al., “Specific IgE to fish extracts does not predict allergy to specific species within an adult fish allergic population,” Clin. Transl. Allergy, vol. 4, no. 1, 2014, doi: 10.1186/2045-7022-4-27.
K. Hamazaki, A. Tsuchida, A. Takamori, T. Tanaka, M. Ito, and H. Inadera, “Dietary intake of fish and ω-3 polyunsaturated fatty acids and physician-diagnosed allergy in Japanese population: The Japan Environment and Children’s Study,” Nutrition, vol. 61, pp. 194–201, May 2019, doi: 10.1016/J.NUT.2018.11.010.
S. L. Taylor, J. L. Kabourek, and S. L. Hefle, “Fish allergy: Fish and products thereof,” Journal of Food Science, vol. 69, no. 8. 2004. doi: 10.1111/j.1750-3841.2004.tb18022.x.
J. Miyata and M. Arita, “Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases,” Allergology International, vol. 64, no. 1. 2015. doi: 10.1016/j.alit.2014.08.003.
S. E. Priani, D. P. Rahayu, and I. T. Maulana, “Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil,” Borneo J. Pharm., vol. 4, no. 2, 2021, doi: 10.33084/bjop.v4i2.1942.
X. M. Mai, A. Langhammer, Y. Chen, and C. A. Camargo, “Cod liver oil intake and incidence of asthma in Norwegian adults - The HUNT study,” Thorax, vol. 68, no. 1, 2013, doi: 10.1136/thoraxjnl-2012-202061.
Badan Pengawas Obat dan Makanan Republik Indonesia, “Keputusan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia Nomor HK.02.01.1.2.08.20.385 Tahun 2020 tentang Penetapan Vitamin D 1000 IU sebagai Suplemen Kesehatan.” Jakarta, 2020.
S. M. Kimball and M. F. Holick, “Official recommendations for vitamin D through the life stages in developed countries,” European Journal of Clinical Nutrition, vol. 74, no. 11. 2020. doi: 10.1038/s41430-020-00706-3.
N. O’Flaherty et al., “135 VITAMIN D FORTIFIED MILK—EFFECT ON VITAMIN D STATUS IN OLDER ADULTS,” Age Ageing, vol. 50, no. Supplement_3, 2021, doi: 10.1093/ageing/afab219.135.
V. Polzonetti, S. Pucciarelli, S. Vincenzetti, and P. Polidori, “Dietary intake of vitamin d from dairy products reduces the risk of osteoporosis,” Nutrients, vol. 12, no. 6. 2020. doi: 10.3390/nu12061743.
M. Temesgen and N. Ratta, “Risk of Lactose Intolerance and Dairy Food Nutrition: A Review,” Food Science and Quality Management, vol. 37. pp. 19–31, 2015.
M. Zahedirad et al., “Fortification aspects of vitamin D in dairy products: A review study,” Int. Dairy J., vol. 94, pp. 53–64, Jul. 2019, doi: 10.1016/J.IDAIRYJ.2019.01.013.
A. M. López-Sobaler, M. Larrosa, M. a. D. Salas-González, A. M. Lorenzo-Mora, V. Loria-Kohen, and A. Aparicio, “Impact of vitamin D on health. Difficulties and strategies to reach the recommended intakes,” Nutr. Hosp., vol. 39, no. Ext3, 2022, doi: 10.20960/nh.04307.
L. H. van Dongen and S. Sahni, “Dairy Products, Vitamin D, and Bone Health,” in Nutritional Influences on Bone Health, 2019. doi: 10.1007/978-3-319-98464-3_18.
S. I. Malyavskaya, “On the importance of implementing the vitamin D deficiency in children and adolescents of the Russian Federation program to improve anti-infectious immunity and long-term health prognosis in children,” Pediatr. Cons. Medicum, no. 4, 2021, doi: 10.26442/26586630.2021.4.201330.
K. M. Junge et al., “Increased Vitamin D levels at birth and in early infancy increase offspring allergy risk - Evidence for involvement of epigenetic mechanisms,” J. Allergy Clin. Immunol., vol. 137, no. 2, 2016, doi: 10.1016/j.jaci.2015.06.040.