TINJAUAN SISTEMATIS HISPATOLOGI GOUT ARTRITIS: PERAN SEL IMUN DALAM PROSES INFLAMASI DAN KERUSAKAN JARINGAN
Main Article Content
Abstract
Gout arthritis is a joint inflammation caused by increased uric acid levels, leading to the formation of monosodium urate (MSU) crystals. The study aimed to deepen the understanding of the role of MSU crystals in triggering both acute and chronic inflammatory responses, as well as the formation of tophi, which damage joint and bone tissues. The method used is the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The reviewed articles were obtained from the Science Direct, Semantic Scholar, and PubMed databases using the keywords “Gout Arthritis,” “Histopathology,” “Inflammation,” and “Tophus.” The publication period was limited to 2019-2024. Out of 745 articles found, 12 were selected based on inclusion criteria, which included experimental, observational, and case study reports. The results show that MSU crystals induce inflammation through the infiltration of inflammatory cells such as neutrophils and macrophages. In chronic Gout, the formation of tophi, granulomatous lesions with a crystalline core, leads to bone and joint destruction. Understanding the histopathological aspects is crucial for more accurate diagnosis and more effective management of Gout arthritis. The progression of the disease is related to acute and chronic inflammation, as well as the destructive effects of tophi on joints and bones. In conclusion, MSU crystals play a significant role in triggering inflammation and tissue damage in Gout arthritis, and understanding histopathology can improve diagnostic accuracy and therapeutic efficacy.
Article Details
References
L. Wilson and J. J. Saseen, “Gouty Arthritis: A Review of Acute Management and Prevention,” Pharmacotherapy, vol. 36, no. 8, pp. 906–922, 2016, doi: 10.1002/phar.1788.
C. Mattiuzzi and G. Lippi, “Recent updates on worldwide gout epidemiology,” Clin. Rheumatol., vol. 39, no. 4, pp. 1061–1063, Apr. 2020, doi: 10.1007/S10067-019-04868-9.
P. Towiwat, A. Chhana, and N. Dalbeth, “The anatomical pathology of gout : a systematic literature review,” BMC Musculoskelet. Disord., pp. 1–14, 2019.
Q. Li et al., “Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements.,” BMJ Open, vol. 9, no. 8, p. e026677., Aug. 2019, doi: 10.1136/bmjopen-2018-026677.
G. Ragab, M. Elshahaly, and T. Bardin, “Gout: An old disease in new perspective – A review,” J. Adv. Res., vol. 8, no. 5, p. 495, Sep. 2017, doi: 10.1016/J.JARE.2017.04.008.
C. Yokose et al., “Radiologic evidence of symmetric and polyarticular monosodium urate crystal deposition in gout - A cluster pattern analysis of dual-energy CT,” Semin. Arthritis Rheum., 2020, doi: 10.1016/J.SEMARTHRIT.2019.07.002.
S.-H. Deng et al., “Differential Diagnosis of Acute and Chronic Gouty Arthritis by Multijoint Ultrasound,” Ultrasound Med. Biol., 2021, doi: 10.1016/j.ultrasmedbio.2021.05.005.
M. J. Page et al., “The PRISMA 2020 statement: An updated guideline for reporting systematic reviews,” BMJ, vol. 372, 2021, doi: 10.1136/bmj.n71.
B. Bengana et al., “Ultrasound Assessment Of Gout Lesions In An Algerian Population With Asymptomatic Hyperuricemia,” Ann. Rheum. Dis., 2021, doi: 10.1136/ANNRHEUMDIS-2021-EULAR.1161.
A. Akhter, A. Mohyeldin, and A. Grossbach, “Acute presentation of spinal gouty arthritis: A case report and review of literature,” Surg. Neurol. Int., vol. 10, 2019, doi: 10.25259/SNI_528_2019.
Z. Doležel, P. Ješina, and B. Stiburkova, “Severe hyperuricemia in two children with acute gastroenteritis: Questions.,” Pediatr. Nephrol., vol. 35, no. 8, pp. 1429–1430, Aug. 2020, doi: 10.1007/s00467-020-04491-w.
M. Rizwan and A. Khan, “Association Of Psoriasis And Serum Uric Acid Levels: A Case Control Study,” Pakistan Armed Forces Med. J., vol. 69, no. 2, pp. 408–412, 2019, [Online]. Available: https://pafmj.org/PAFMJ/article/view/2764
S. Aboud Essa and A. Khairi Mishari, “Association Between Serum Uric Acid And Obesity,” J. Babylon Univ. Appl. Sci., vol. 2, no. 23, pp. 899–903, 2015.
C.-Y. Qiao et al., “Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages,” Inflammopharmacology, vol. 28, pp. 1481–1493, 2020, doi: 10.1007/s10787-020-00758-8.
P. Agarwal, V. Kaushik, and S. Chand, “Tophaceous Gout with Multiple Unusual Large Tophi and Severe Joints Destruction – A Pictorial Case Report,” Indian Pract., vol. 70, pp. 22–25, 2017.
C. Jerome, B. Hoch, and C. S. Carlson, Skeletal System. Elsevier Inc., 2017. doi: 10.1016/B978-0-12-802900-8.00005-1.
C. Pineda et al., “Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout.,” Arthritis Res. Ther., vol. 17, no. 1, p. 37, Feb. 2015, doi: 10.1186/s13075-015-0550-4.
M. Wang et al., “Single-Cell Analysis in Blood Reveals Distinct Immune Cell Profiles in Gouty Arthritis,” J. Immunol., 2023, doi: 10.4049/jimmunol.2200422.
F. Renaudin et al., “Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.,” Ann. Rheum. Dis., vol. 79, no. 11, pp. 1506–1514, Nov. 2020, doi: 10.1136/annrheumdis-2020-217342.
C. Liao et al., “Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression,” Redox Biol., vol. 28, 2019, doi: 10.1016/j.redox.2019.101306.