PENGARUH SEROTONIN TERHADAP PERUBAHAN MOOD PADA REMAJA WANITA PREMENSTRUAL SYNDROME
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Abstract
A woman's regular monthly menstruation is positive indicator of health. However, majority of women have negative effects from symptoms arising during the second half of the menstrual cycle. This study aims to determine the effect of serotonin on mood changes in adolescent girls suffering from PMS and who don't. This research was conducted in April-July 2023 at Darul Arqam in Makassar. The research used a cross-sectional design with a sample size of 48 young women consisting of two groups, 24 groups with PMS and 24 without PMS, selected using purposive sampling. Mann-Whitney and Kruskall-Wallis analyses were used to examine the effect of serotonin on changes in mood and menstrual patterns in adolescent girls with and without PMS. The finding showed that there were differences in serotonin levels between groups of women who experienced PMS and those who did not experience PMS, with a value of p=0.012 p<α=0.05. The findings showed an influence of serotonin levels in the group of women who experienced PMS on mood changes (p = 0.001). In the group of women who did not experience PMS, serotonin levels did not influence mood changes (p = 0.875). Serotonin influences mood changes in women who experience PMS. However, serotonin does not have positive or negative effects on women who have not experienced PMS. There are differences in serotonin levels between women who experience PMS and those who don't. This study recommends to explore alternative treatment options for managing PMS symptoms that do not rely solely on serotonin regulation.
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References
F. Petraglia, M. Bernardi, L. Lazzeri, F. Perelli, and F. M. Reis, "Dysmenorrhea and related disorders," F1000Research, vol. 6, no. 0, pp. 1–7, 2017, doi: 10.12688/f1000research.11682.1.
H. Işik, Ş. Ergöl, Ö. Aynioğlu, A. Şahbaz, A. Kuzu, and M. Uzun, "Premenstrual syndrome and life quality in Turkish health science students," Turkish J. Med. Sci., vol. 46, no. 3, pp. 695–701, 2016, doi: 10.3906/sag-1504-140.
W. T. R. Purba, M. B. Azhar, and E. Roflin, "Association of Dysmenorrhea and Quality of Life in Female Stundents At Xaverius I Senior High School Palembang Academic Year 2018-2019," Maj. Kedokt. Sriwij., vol. 51, no. 1, pp. 23–29, 2019, doi: 10.32539/mks.v51i1.8568.
U. C. Igbokwe and Y. O. Akinola, "menstrual disorder and treatment seeking behavior Ibadan," Dep. Heal. Promot. Educ. Niger., vol. 19, no. 1, pp. 40–48, 2021.
R. Firoozi, M. Kafi, I. Salehi, and M. Shirmohammadi, "The relationship between severity of premenstrual syndrome and psychiatric symptoms," Iran. J. Psychiatry, vol. 7, no. 1, pp. 36–40, 2012.
T. Pearlstein and A. B. Stone, "Premenstrual syndrome," Psychiatr. Clin. North Am., vol. 21, no. 3, pp. 577–590, 1998, doi: 10.1016/S0193-953X(05)70024-1.
Y. J. Kim and Y. J. Park, "Menstrual cycle characteristics and premenstrual syndrome prevalence based on the daily record of severity of problems in Korean young adult women," J. Korean Acad. Nurs., vol. 50, no. 1, pp. 147–157, 2020, doi: 10.4040/jkan.2020.50.1.147.
J. C. Lee, B. K. Yu, J. H. Byeon, K. H. Lee, J. H. Min, and S. H. Park, "A study on the menstruation of Korean adolescent girls in Seoul," Korean J. Pediatr., vol. 54, no. 5, pp. 201–206, 2011, doi: 10.3345/kjp.2011.54.5.201.
A. Ryu and T. H. Kim, "Premenstrual syndrome: A mini review," Maturitas, vol. 82, no. 4, pp. 436–440, 2015, doi: 10.1016/j.maturitas.2015.08.010.
C. I. Jarvis, A. M. Lynch, and A. K. Morin, "Management strategies for premenstrual syndrome/premenstrual dysphoric disorder," Ann. Pharmacother., vol. 42, no. 7–8, pp. 967–978, 2008, doi: 10.1345/aph.1K673.
P. K. Braverman, "Premenstrual Syndrome and Premenstrual Dysphoric Disorder," J. Pediatr. Adolesc. Gynecol., vol. 20, no. 1, pp. 3–12, 2007, doi: 10.1016/j.jpag.2006.10.007.
Green LJ, O. PMS, and Panay, "Management of Premenstrual Syndrome," BJOG An Int. J. Obstet. Gynaecol., vol. 124, no. 3, pp. e73–e105, 2017, doi: 10.1111/1471-0528.14260.
S. Walsh, E. Ismaili, B. Naheed, and S. O'Brien, "Diagnosis, pathophysiology and management of premenstrual syndrome," Obstet. Gynaecol., vol. 17, no. 2, pp. 99–104, 2015, doi: 10.1111/tog.12180.
G. Albatran, "Prevalence Pattern and Predictors of Premenstrual Syndrome and Premenstrual Dysphoric Disorder among Urban Women," J. Popul. Ther. Clin. Pharmacol., vol. 30, no. 16, pp. e325–e329, 2023, doi: 10.47750/jptcp.2023.30.16.044.
F. W. Tolossa and M. L. Bekele, "Prevalence, impacts and medical managements of premenstrual syndrome among female students: Cross-sectional study in college of health sciences, Mekelle University, Mekelle, Northern Ethiopia," BMC Womens. Health, vol. 14, no. 1, pp. 1–9, 2014, doi: 10.1186/1472-6874-14-52.
A. J. Rapkin and S. A. Winer, "The pharmacologic management of premenstrual dysphoric disorder," Expert Opin. Pharmacother., vol. 9, no. 3, pp. 429–445, 2008, doi: 10.1517/14656566.9.3.429.
P. Michael, S. O. Brien, C. Brown, J. Endicott, and E. Freeman, "Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus," Arch Womens Ment Heal., vol. 14, no. 1, pp. 13–21, 2014, doi: 10.1007/s00737-010-0201-3.Towards.
E. W. Freeman, K. Rickels, M. D. Sammel, H. Lin, and S. J. Sondheimer, “Time to Relapse After Short-Term or Long-Term Sertraline Treatment for Severe Premenstrual Syndromes,” Arch Gen Psychiatry, vol. 66, no. 5, pp. 537–544, 2009, doi: 10.1001/archgenpsychiatry.2008.547.Time.
L. J. Baker and P. M. S. O'Brien, "Premenstrual syndrome (PMS): A peri-menopausal perspective," Maturitas, vol. 72, no. 2, pp. 121–125, 2012, doi: 10.1016/j.maturitas.2012.03.007.
M. Carlsson and A. Carlsson, "A regional study of sex differences in rat brain serotonin," Prog. Neuropsychopharmacol. Biol. Psychiatry, vol. 12, no. 1, pp. 53–61, 1988, doi: 10.1016/0278-5846(88)90061-9.
D. R. Rubinow et al., "Changes in plasma hormones across the menstrual cycle in patients with menstrually related mood disorder and in control subjects," Am. J. Obstet. Gynecol., vol. 158, no. 1, pp. 5–11, 1988, doi: 10.1016/0002-9378(88)90765-X.
C. L. Bethea, N. Z. Lu, C. Gundlah, and J. M. Streicher, "Diverse actions of ovarian steroids in the serotonin neural system," Front. Neuroendocrinol., vol. 23, no. 1, pp. 41–100, 2002, doi: 10.1006/frne.2001.0225.
M. Landén, O. Eriksson, C. Sundblad, B. Andersch, T. Naessén, and E. Eriksson, "Compounds with affinity for serotonergic receptors in the treatment of premenstrual dysphoria: A comparison of buspirone, nefazodone and placebo," Psychopharmacology (Berl)., vol. 155, no. 3, pp. 292–298, 2001, doi: 10.1007/s002130100718.
M. Zendehdel and F. Elyasi, "Biopsychosocial etiology of premenstrual syndrome: A narrative review," J. Fam. Med. Prim. Care, vol. 7, no. 2, pp. 346–356, 2018, doi: 10.4103/jfmpc.jfmpc.
Allen, McBride, and Pirie, "The shortened premenstrual assessment form," J Reprod Med, vol. 36, no. 11, pp. 769–772, 1991.
C. Huang and J. H. Chen, "Meta-Analysis of the Factor Structures of the Beck Depression Inventory–II," Assessment, vol. 22, no. 4, pp. 459–472, 2015, doi: 10.1177/1073191114548873.
B. Dilbaz and A. Aksan, "Premenstrual syndrome, a common but underrated entity: Review of the clinical literature," J. Turkish Ger. Gynecol. Assoc., vol. 22, no. 2, pp. 139–148, 2021, doi: 10.4274/jtgga.galenos.2021.2020.0133.
Rodiani and A. Rusfiana, “Hubungan Premenstrual Syndrome (PMS)terhadap Faktor Psikologis pada Remaja,” HubunganPremenstrual Syndr. terhadap Fakt. Psikologis pada Remaja, vol. 5, no. 1, pp. 18–22, 2016, [Online]. Available: http://journal.unair.ac.id/download-fullpapers-aunf37edc8630full.pdf
L. Tiranini and R. E. Nappi, "Recent advances in understanding/management of premenstrual dysphoric disorder/premenstrual syndrome," Fac. Rev., vol. 11, no. 11, 2022, doi: 10.12703/r/11-11.
M. Wu, Y. Liang, Q. Wang, Y. Zhao, and R. Zhou, "Emotion Dysregulation of Women with Premenstrual Syndrome," Sci. Rep., vol. 6, no. November, pp. 1–10, 2016, doi: 10.1038/srep38501.
I. Kwan and J. L. Onwude, "Premenstrual syndrome," BMJ Clin. Evid., vol. 2015, no. April 2014, pp. 1–13, 2015.
B. N. Sanchez, W. J. Kraemer, and C. M. Maresh, "Premenstrual Syndrome and Exercise: A Narrative Review," Women, vol. 3, no. 2, pp. 348–364, 2023, doi: 10.3390/women3020026.
J. Witkoś and M. Hartman-Petrycka, "The influence of running and dancing on the occurrence and progression of premenstrual disorders," Int. J. Environ. Res. Public Health, vol. 18, no. 15, pp. 1–16, 2021, doi: 10.3390/ijerph18157946.
M. K. B. Lustyk, L. Widman, A. Paschane, and E. Ecker, "Stress, quality of life and physical activity in women with varying degrees of premenstrual symptomatology," Women Heal., vol. 39, no. 3, pp. 35–44, 2004, doi: 10.1300/J013v39n03_03.
H. Kahyaoglu Sut and E. Mestogullari, "Effect of Premenstrual Syndrome on Work-Related Quality of Life in Turkish Nurses," Saf. Health Work, vol. 7, no. 1, pp. 78–82, 2016, doi: 10.1016/j.shaw.2015.09.001.
A. M. Al-Shahrani et al., "Premenstrual syndrome and its impact on the quality of life of female medical students at bisha university, saudi arabia," J. Multidiscip. Healthc., vol. 14, pp. 2373–2379, 2021, doi: 10.2147/JMDH.S327893.
R. I. Teleanu, A. G. Niculescu, E. Roza, O. Vladâcenco, A. M. Grumezescu, and D. M. Teleanu, "Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System," Int. J. Mol. Sci., vol. 23, no. 11, pp. 1–24, 2022, doi: 10.3390/ijms23115954.
S. Breit, A. Kupferberg, G. Rogler, and G. Hasler, "Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders," Front. Psychiatry, vol. 9, no. MAR, pp. 1–15, 2018, doi: 10.3389/fpsyt.2018.00044.
M. Krakowski, "Violence and serotonin: Influence of impulse control, affect regulation, and social functioning," J. Neuropsychiatry Clin. Neurosci., vol. 15, no. 3, pp. 294–305, 2003, doi: 10.1176/jnp.15.3.294.
M. Cahir, T. C. Ardis, J. J. Elliott, C. B. Kelly, G. P. Reynolds, and S. J. Cooper, "Acute tryptophan depletion does not alter central or plasma brain-derived neurotrophic factor in the rat," Eur. Neuropsychopharmacol., vol. 18, no. 5, pp. 317–322, 2008, doi: 10.1016/j.euroneuro.2007.07.006.
C. N. Yohn, M. M. Gergues, and B. A. Samuels, "The role of 5-HT receptors in depression Tim Bliss," Mol. Brain, vol. 10, no. 1, pp. 1–12, 2017, doi: 10.1186/s13041-017-0306-y.
T. A. Jenkins, J. C. D. Nguyen, K. E. Polglaze, and P. P. Bertrand, "Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis," Nutrients, vol. 8, no. 1, pp. 1–15, 2016, doi: 10.3390/nu8010056.