EFEKTIVITAS SEDUHAN DAUN ASAM JAWA TERHADAP KADAR HOMA-IR DAN HOMA-β PADA PASIEN DIABETES MELLITUS TIPE 2
Isi Artikel Utama
Abstrak
This study assessed the impact of tamarind leaf tea on HOMA-IR and HOMA-β levels in patients with Type 2 Diabetes Mellitus (DM). Thirty-two patients aged 20-50 years from Sungai Ambawang District Health Center, who were not using any DM medication, participated. They were divided into control (KN) and treatment (KP) groups, with KP receiving a tamarind leaf tea infusion for 7 days. HOMA-IR and HOMA-β levels were calculated using standardized formulas based on fasting insulin and glucose levels. The Wilcoxon signed-rank test revealed a significant decrease in HOMA-IR levels in the KP group (p<0.05), while no significant change was observed in the KN group. Although no significant difference in HOMA-β levels was found between the two groups, the KP group showed a notable increase by 4. These findings suggest that a 7-day tamarind leaf tea infusion effectively reduced HOMA-IR levels in patients with type 2 DM, although it did not significantly affect HOMA-β levels. This study highlights the potential of tamarind leaf tea as a complementary approach for managing insulin resistance in Type 2 DM patients. Further research is needed to explore the long-term effects and mechanisms of action for improving β-cell function. The conclusion of this study is that steeping tamarind leaves for seven days can reduce HOMA-I levels and slightly increase HOMA-β levels in patients with type 2 Diabetes Mellitus.
Rincian Artikel
Referensi
S. K. Indonesia, Survei Kesehatan Indonesia dalam Angka, vol. 01. Kementerian Kesehatan Republik Indonesia Badan Kebijakan Pembangunan Kesehatan, 2023.
D. Mirja Togubu, G. D. Dirawan, and N. Pertiwi, “Pengaruh Minat Masyarakat Terhadap Perilaku Pencegahan Penyakit Diabetes Melitus,” UNM Environ. Journals, vol. 6, no. April, pp. 1–6, 2023, [Online]. Available: https://doi.org/10.26858/uej.v6i2.
P. Rorsman and F. M. Ashcroft, “Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.,” Physiol. Rev., vol. 98, no. 1, pp. 117–214, Jan. 2018, doi: 10.1152/physrev.00008.2017.
R. J. Tiurma and Syahrizal, “Obesitas Sentral dengan Kejadian Hiperglikemia pada Pegawai Satuan Kerja Perangkat Daerah,” Higeia J. Public Heal. Res. Dev., vol. 5, no. 3, pp. 227–238, 2021.
E. Banjarnahor and S. Wangko, “Sel Beta Pankreas Sintesis Dan Sekresi Insulin,” J. Biomedik, vol. 4, no. 3, 2013, doi: 10.35790/jbm.4.3.2012.795.
R. Ruze et al., “Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatment,” Front. Endocrinol. (Lausanne)., vol. 14, p. 1161521, 2023, doi: 10.3389/fendo.2023.1161521.
D. Novia, S. Sugiarto, and Y. L. Dewi, “Pengaruh Dosis Dan Lama Pemberian Ekstrak Daun Asam Jawa (Tamarindus Indica Linn) Terhadap Homa-Β Pada Tikus Model Diabetes Mellitus Tipe 2 The effect of Tamarind Leaf (tamarindus indica linn) Extract on HOMA-β in Rats with Type 2 Diabetes Mellitus Model,” Media Gizi Indones., vol. 16, no. 3, p. 267, 2021, doi: 10.20473/mgi.v16i3.267-272.
K.-C. Sung, G. M. Reaven, and S. H. Kim, “Utility of homeostasis model assessment of beta-cell function in predicting diabetes in 12,924 healthy Koreans.,” Diabetes Care, vol. 33, no. 1, pp. 200–202, Jan. 2010, doi: 10.2337/dc09-1070.
C. H. Lee et al., “Optimal Cut-Offs of Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) to Identify Dysglycemia and Type 2 Diabetes Mellitus: A 15-Year Prospective Study in Chinese.,” PLoS One, vol. 11, no. 9, p. e0163424, 2016, doi: 10.1371/journal.pone.0163424.
R. Muniyappa, S. Lee, H. Chen, and M. J. Quon, “Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.,” Am. J. Physiol. Endocrinol. Metab., vol. 294, no. 1, pp. E15-26, Jan. 2008, doi: 10.1152/ajpendo.00645.2007.
Y. Saisho, “β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes.,” World J. Diabetes, vol. 6, no. 1, pp. 109–124, Feb. 2015, doi: 10.4239/wjd.v6.i1.109.
P. Poltak, S. Syafril, and R. A. Ganie, “Hubungan kadar TNF-α dengan HOMA-IR pada pasien diabetes mellitus tipe-2 di Rumah Sakit Umum Pusat Haji Adam Malik, Medan, Indonesia,” Intisari Sains Medis, vol. 10, no. 3, pp. 580–583, 2019, doi: 10.15562/ism.v10i3.467.
L. V Nedosugova et al., “Inflammatory Mechanisms of Diabetes and Its Vascular Complications.,” Biomedicines, vol. 10, no. 5, May 2022, doi: 10.3390/biomedicines10051168.
A. Vinuesa et al., “Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease.,” Front. Neurosci., vol. 15, p. 653651, 2021, doi: 10.3389/fnins.2021.653651.
E. Marfianti, “Perbedaan Kadar Resistin Pada Obes Dengan Resistensi Insulin Dan Obes Tanpa Resistensi Insulin,” J. Kedokt. dan Kesehat. Indones., vol. 1, no. 1, pp. 45–52, 2009, doi: 10.20885/jkki.vol1.iss1.art6.
A. Puspasari, C. Maharani, R. Mus, P. Hastuti, A. Hamim Sadewa, and Setyawati, “Biomarker Pengganti Homa-Ir untuk Mendeteksi Resistensi Insulin,” Jmj, vol. 7, no. 2, pp. 122–130, 2019.
N. G. Forouhi et al., “Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study.,” lancet. Diabetes Endocrinol., vol. 2, no. 10, pp. 810–818, Oct. 2014, doi: 10.1016/S2213-8587(14)70146-9.
A. Kautzky-Willer, J. Harreiter, and G. Pacini, “Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus.,” Endocr. Rev., vol. 37, no. 3, pp. 278–316, Jun. 2016, doi: 10.1210/er.2015-1137.
A. Kautzky-Willer, M. Leutner, and J. Harreiter, “Sex differences in type 2 diabetes,” Diabetologia, vol. 66, no. 6, pp. 986–1002, 2023, doi: 10.1007/s00125-023-05891-x.
N. Lascar, J. Brown, H. Pattison, A. H. Barnett, C. J. Bailey, and S. Bellary, “Type 2 diabetes in adolescents and young adults.,” lancet. Diabetes Endocrinol., vol. 6, no. 1, pp. 69–80, Jan. 2018, doi: 10.1016/S2213-8587(17)30186-9.
S. Adisakwattana, P. Jiphimai, P. Prutanopajai, B. Chanathong, S. Sapwarobol, and T. Ariyapitipan, “Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants.,” Int. J. Food Sci. Nutr., vol. 61, no. 3, pp. 295–305, May 2010, doi: 10.3109/09637480903455963.
M. F. Mahomoodally, A. Gurib-Fakim, and A. H. Subratty, “Antimicrobial activities and phytochemical profiles of endemic medicinal plants of Mauritius,” Pharm. Biol., vol. 43, no. 3, pp. 237–242, 2005, doi: 10.1080/13880200590928825.
D. M. Kurniawati, E. Dharmana, B. Rachmawati, and T. G. D. Pemayun, “Pengaruh pemberian ekstrak kedelai hitam (Glycine soja.) berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR,” J. Gizi Indones. (The Indones. J. Nutr., vol. 6, no. 1, pp. 44–50, 2017, doi: 10.14710/jgi.6.1.44-50.
R. Alfian, “Korelasi Antara Kepatuhan Minum Obat dengan Kadar Gula Darah pada Pasien Diabetes Melitus,” J. Pharmascience, vol. 2, no. 2, pp. 15–23, 2015, [Online]. Available: https://ppjp.ulm.ac.id/journal/index.php/pharmascience/article/view/5818/4874.
S. J. Martina et al., “The decreasing of homeostatic model assessment – insulin resistance levels after given coffee arabica gayo leaf extract (Coffea arabica l.) to type 2 diabetes mellitus rats,” Open Access Maced. J. Med. Sci., vol. 9, no. A, pp. 356–361, 2021, doi: 10.3889/oamjms.2021.5984.
L. Chen et al., “Antidiabetic effect of sciadonic acid on type 2 diabetic mice through activating the PI3K-AKT signaling pathway and altering intestinal flora.,” Front. Nutr., vol. 9, p. 1053348, 2022, doi: 10.3389/fnut.2022.1053348.
B. Russo, F. Picconi, I. Malandrucco, and S. Frontoni, “Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials.,” Int. J. Mol. Sci., vol. 20, no. 9, Apr. 2019, doi: 10.3390/ijms20092061.
K.-C. Shih and C.-F. Kwok, “Exercise reduces body fat and improves insulin sensitivity and pancreatic β-cell function in overweight and obese male Taiwanese adolescents.,” BMC Pediatr., vol. 18, no. 1, p. 80, Feb. 2018, doi: 10.1186/s12887-018-1025-y.
X. Yu, P. Chen, H. Wang, H. Jin, W. Jia, and L. Wang, “Clinical study of exercise on improvement of β-cell function and insulin resistance in non-diabetic young offsprings of diabetic patients.,” J. Endocrinol. Invest., vol. 37, no. 4, pp. 353–358, Apr. 2014, doi: 10.1007/s40618-013-0033-x.
D. Khalili et al., “Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes?,” BMC Endocr. Disord., vol. 23, no. 1, pp. 1–9, 2023, doi: 10.1186/s12902-023-01291-9.
M.-A. Ghaffari, S.-A. Payami, S.-P. Payami, D. Ashtary-Larky, A. Nikzamir, and G. Mohammadzadeh, “Evaluation of Insulin Resistance Indices in Type 2 Diabetic Patients Treated with Different Anti-Diabetic Drugs,” Open J. Endocr. Metab. Dis., vol. 06, no. 02, pp. 95–101, 2016, doi: 10.4236/ojemd.2016.62013.
A. S. Havulinna et al., “Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort.,” Arterioscler. Thromb. Vasc. Biol., vol. 36, no. 12, pp. 2424–2430, Dec. 2016, doi: 10.1161/ATVBAHA.116.307497.
A. E. Nugroho, “Review : Animal Models Of Diabetes Mellitus : Pathology And Mechanism Of Some Diabetogenics,” Biodiversitas J. Biol. Divers., vol. 7, no. 4, pp. 378–382, 2006, doi: 10.13057/biodiv/d070415.
M. E. Cerf, “Beta cell dysfunction and insulin resistance.,” Front. Endocrinol. (Lausanne)., vol. 4, p. 37, 2013, doi: 10.3389/fendo.2013.00037.
U. Galicia-Garcia et al., “Pathophysiology of Type 2 Diabetes Mellitus.,” Int. J. Mol. Sci., vol. 21, no. 17, Aug. 2020, doi: 10.3390/ijms21176275.
K. J. Chang-Chen, R. Mullur, and E. Bernal-Mizrachi, “Beta-cell failure as a complication of diabetes.,” Rev. Endocr. Metab. Disord., vol. 9, no. 4, pp. 329–343, Dec. 2008, doi: 10.1007/s11154-008-9101-5.
H. Kaneto, N. Katakami, M. Matsuhisa, and T. Matsuoka, “Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.,” Mediators Inflamm., vol. 2010, p. 453892, 2010, doi: 10.1155/2010/453892.
S. Lenzen, “Chemistry and biology of reactive species with special reference to the antioxidative defence status in pancreatic β-cells.,” Biochim. Biophys. acta. Gen. Subj., vol. 1861, no. 8, pp. 1929–1942, Aug. 2017, doi: 10.1016/j.bbagen.2017.05.013.
N. Wibisono, A. Basori, and S. Suhartati, “Efek Pemberian Ekstrak Etanol Daun Jarak Merah (Jatropha gossypiifolia L.) terhadap Kadar Glukosa Darah Puasa, Kadar Insulin Serum dan HOMA-IR …,” J. Kesehat. Islam Islam. Heal. J., vol. 11, 2022.
O. T. Lahamado, S. M. Sabang, and K. Mustapa, “Ekstrak Daun Asam Jawa (Tamarindus Indica L.) Sebagai Anti-diabetes,” J. Akad. Kim., vol. 6, no. 1, p. 1, 2017, doi: 10.22487/j24775185.2017.v6.i1.9221.
E. Yunita, S. Fatimah, D. Yulianto, V. Trikuncahyo, and Z. Khodijah, “Potensi Daun Asam Jawa (Tamarindus indica L.) sebagai Alternatif Antiinflamasi: STUDI IN SILICO,” J. Kefarmasian Akfarindo, vol. 4, no. 2, pp. 42–50, 2019, doi: 10.37089/jofar.v0i0.68.